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These include: Gallstones and gallbladder issues, thought to be caused by rapid weight loss Pancreatitis studies have shown a higher risk for this condition while taking GLP-1 medications compared to other weight loss medications Gastroparesis (delayed stomach emptying) though these medications are designed to slow down digestion, if it slows down too much, it can lead to other symptoms and complications

Quality sleep further enhances results, as GH is primarily secreted during deep sleep

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The mechanism of action involved inhibition of sphingosine kinase 1 (SphK1), a sphingosine-1-phosphate (S1P)-producing enzyme, along with STAT3 and NF-Bp65, which are involved in chemokine production [91]

Ongoing clinical trials, including studies specifically examining NASH outcomes, may inform future prescribing guidance